Effects of multivitamin combined with magnesium sulfate versus magnesium sulfate alone on hemodynamics, coagulation, and maternal-infant outcomes in preeclampsia: a randomized controlled study.

Plain-language guide to PMID 41476304 (2025): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 194 women.

Key Facts

PMID: 41476304
Journal: Journal of health, population, and nutrition
Year: 2025
Study type: Randomized Controlled Trial
Authors: Gao S et al. (7 authors)
DOI: 10.1186/s41043-025-01199-1

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To explore the effects of multivitamin combined with magnesium sulfate on placental hemodynamics, coagulation function, and maternal and infant outcomes in preeclampsia patients.

Who Took Part

According to the abstract, 194 women were involved.

PubMed indexes the participants as adults, women only.

A randomized controlled study was conducted among 194 pregnant women diagnosed with preeclampsia between April 2022 and April 2023.

Participants were randomly assigned to either the control group (n = 97), receiving intravenous magnesium sulfate alone, or the observation group (n = 97), receiving magnesium sulfate combined with multivitamin supplementation.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The treatment duration for both groups was two weeks.

Blood pressure, 24-hour urinary protein, placental Doppler indices (RI, PI, S/D), coagulation markers (PT, APTT, FIB, TT), and maternal-infant outcomes were measured and compared.

What Was Measured

PubMed files the paper under topics including Magnesium Sulfate, Pre-Eclampsia, Hemodynamics, Vitamins, Blood Coagulation, Dietary Supplements and Pregnancy Outcome.

The authors tagged it with the keywords Multivitamins, Preeclampsia and Therapeutic effect.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 194 women.

The abstract goes on to report its results in about 13 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Journal of health, population, and nutrition), a journal based in Bangladesh.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.