Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in the context of fatty liver & elevated liver enzymes, published as a meta-analysis.

A random-effects model was used to determine the mean change in the standard mean difference for various variables, including insulin, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglycerides (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST).

Why It Was Studied

Vitamin D supplementation has been proposed as a therapeutic strategy for metabolic dysfunction-associated fatty liver disease (MAFLD); however, clinical evidence remains conflicting.

Who the Included Studies Covered

After analyzing and screening 2123 studies, 21 studies meeting the eligibility criteria for meta-analysis were selected.

How the Review Was Done

The researchers searched PubMed, EMBASE, Web of Science, and the Cochrane Library, extending until April 2025.

Heterogeneity was assessed using I2 in the analysis, and subgroup analysis was conducted to identify the sources of heterogeneity.

What Was Measured

The subject headings attached to it are Vitamin D, Dietary Supplements, Randomized Controlled Trials as Topic, Insulin Resistance, Blood Glucose, Fatty Liver and Insulin.

The authors tagged it with the keywords glucose and lipid metabolism, liver function, meta-analysis, metabolic-associated fatty liver disease and vitamin D supplement.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in people with fatty liver & elevated liver enzymes.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, Fatty liver & elevated liver enzymes research.