← Human Trials & Peer-Reviewed Studies
Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial
Plain-language guide to PMID 41484640 (2026): double-blind randomized controlled trial study of Cyanocobalamin (Vitamin B12), lupus (sle).
Key Facts
- PMID
- 41484640
- Journal
- Clinical epigenetics
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- da Mota JCNL et al. (11 authors)
- DOI
- 10.1186/s13148-025-02041-5
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in the context of lupus (sle) in this randomized controlled trial publication.
DNA methylation plays an important role in systemic lupus erythematosus (SLE) pathogenesis by regulating immune cell function and disease progression.
Dietary factors, particularly methyl-donor micronutrients such as folic acid and vitamin B12, may influence DNA methylation patterns and autoimmune responses.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, women only.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Cyanocobalamin (Vitamin B12) group a baseline to be compared against.
Phenotypic characteristics and adipose tissue DNA methylation profiles were assessed before and after intervention using the Illumina EPIC BeadChip platform.
What Was Measured
PubMed files the paper under topics including Vitamin B 12, DNA Methylation, Lupus Erythematosus, Systemic, Folic Acid, Dietary Supplements, Adipose Tissue and Nutritional Status.
Author keywords: Epigenetics, Obesity, Precision nutrition and Systemic lupus erythematosus.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in people with lupus (sle).
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2026 (Clinical epigenetics), a journal based in Germany.
More context: the Cyanocobalamin (Vitamin B12) compound page, Lupus (SLE) research.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.