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The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.
Plain-language guide to PMID 41570758 (2026): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 41570758
- Journal
- American journal of otolaryngology
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- Tavakoli B et al. (2 authors)
- DOI
- 10.1016/j.amjoto.2026.104793
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Given the high prevalence of vitamin D deficiency among sudden sensorineural hearing loss (SSNHL) patients, this study endeavours to evaluate the impact of incorporating vitamin D supplementation into the standard treatment for individuals confirmed to be vitamin D deficient.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Patients were assessed for pure-tone average (PTA) frequencies of 500, 1000, 2000, 4000, and 6000 Hz, speech reception threshold (SRT), and speech discrimination score (SDS) at baseline, 10th, and 30-day follow-up.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
PubMed files the paper under topics including Pilot Projects, Hearing Loss, Sensorineural, Vitamin D Deficiency, Hearing Loss, Sudden, Dietary Supplements, Vitamin D and Vitamins.
Author keywords: Pure-tone average, Sensory-neural hearing loss and Speech discrimination score.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2026 (American journal of otolaryngology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.