Cardiometabolic implications of triglyceride-glucose index, remnant cholesterol, and vitamin D in normoglycemic Arab adolescents: a cross-sectional study.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc.

Logistic models include Hosmer-Lemeshow and AUC metrics to assess calibration and discrimination.

Why It Was Studied

The triglyceride-glucose (TyG) index, remnant cholesterol (RC), and vitamin D deficiency (VDD) are linked to cardiovascular diseases (CVDs) in adults.

Nonetheless, their interplay in adolescents remains unclear.

Who Took Part

The abstract describes 4,865 adolescents taking part.

By PubMed's age tags, the people studied were children and teenagers, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Anthropometrics, blood pressure (BP), fasting glucose (FG) and lipid profile, and serum 25(OH)D were measured using standardized procedures.

TyG and RC were calculated and analyzed as both continuous variables and by tertiles.

Associations with cardiometabolic outcomes were assessed using multivariable linear and logistic regression adjusted for age and BMI; p-values were corrected for multiple testing using the False Discovery Rate (FDR) (Benjamini-Hochberg).

What Was Measured

Topics PubMed links to this paper include Cross-Sectional Studies, Triglycerides, Vitamin D, Blood Glucose, Saudi Arabia, Cholesterol and Vitamin D Deficiency.

Author keywords: adolescents, cardiovascular diseases, insulin resistance and remnant cholesterol.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 4,865 adolescents.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Frontiers in endocrinology), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.