Calcium and vitamin D reduce hypoparathyroidism and hospital stay after thyroidectomy: A randomized controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Transient hypoparathyroidism is a common complication after total thyroidectomy, prolonging hospitalization and necessitating calcium and/or vitamin D replacement.

Who Took Part

According to the abstract, 600 patients were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

In this single-center, prospective, randomized, controlled, open-label trial, 600 patients undergoing total thyroidectomy without central neck dissection were randomized to receive prophylactic oral calcium carbonate/gluconate and alfacalcidol (group A, n = 300) or standard postoperative care (group B, n = 300).

How the Study Was Run

The researchers set it up as a randomized and open-label study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the patients and staff both knew the treatment.

Primary outcomes were biochemical and symptomatic hypocalcemia and the need for intravenous calcium.

Secondary outcomes included postoperative serum calcium levels and length of hospital stay.

What Was Measured

The subject headings attached to it are Calcium, Calcium Carbonate, Calcium Gluconate, Hydroxycholecalciferols, Hypocalcemia, Hypoparathyroidism and Length of Stay.

What This Means in Plain Language

The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc in 600 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (Surgery), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.