Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trial

What Was Tested

This randomized controlled trial paper looks at Cyanocobalamin (Vitamin B12) in the context of chronic pain: fibromyalgia & crps.

Chronic low back pain is one of the leading causes of disability.

Who Took Part

The abstract describes 163 patients taking part.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

A total of 163 patients with chronic mechanical lower back pain were included and assigned to receive TPH plus NSAIDs (n=81) or placebo plus NSAIDs (n=82).

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.

Some patients received a placebo instead of Cyanocobalamin (Vitamin B12), giving a reference point.

A randomized, double-blind, phase 3 clinical trial was conducted across six centers in Peru.

Analyses were performed using an intention-to-treat approach and models adjusted for covariates.

What Was Measured

The subject headings attached to it are Thiamine, Low Back Pain, Pyridoxine, Chronic Pain, Vitamin B Complex, Anti-Inflammatory Agents, Non-Steroidal and Vitamin B 12.

Author keywords: Biomarcadores de seguridad de fármacos, Complejo vitamínico B, Dolor lumbar, Drug evaluation, Ensayo clínico controlado aleatorizado and Evaluación de eficacia-efectividad de intervenciones.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 163 patients in people with chronic pain: fibromyalgia & crps.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (Medicina clinica), a journal based in Spain.

More context: the Cyanocobalamin (Vitamin B12) compound page, Chronic pain: fibromyalgia & CRPS research.