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Serum magnesium is linked with sperm concentration, motile sperm count and serum anti-Müllerian hormone in infertile men.
Plain-language guide to PMID 41653852 (2026): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 330 men.
Key Facts
- PMID
- 41653852
- Journal
- Reproductive biomedicine online
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- Yahyavi SK et al. (7 authors)
- DOI
- 10.1016/j.rbmo.2025.105232
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
What is the relationship between serum magnesium, semen quality and reproductive hormones in infertile men?
Who Took Part
The study group was 330 men.
By PubMed's age tags, the people studied were adults, men only.
Each participant underwent a physical examination and had blood and semen parameters assessed.
Thirty-one men were excluded due to missing serum magnesium, leaving 299 men stratified by serum magnesium tertile.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
Topics PubMed links to this paper include Anti-Mullerian Hormone, Cholecalciferol, Infertility, Male, Magnesium, Sperm Count, Sperm Motility and Secondary Data Analysis.
Author keywords: Semen quality, Serum AMH, Serum magnesium and Vitamin D.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 330 men.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2026 (Reproductive biomedicine online), a journal based in Netherlands.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.