Gestational Age-Dependent Effects of Antenatal Magnesium Sulfate on Fetal S100B Levels: An Observational Study Using Cord Serum.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

Magnesium sulfate (MgSO4) is widely used for fetal neuroprotection in preterm births before 32 weeks of gestation, yet it remains unclear whether its effect depends on gestational age.

S100 calcium-binding protein B (S100B), a protein secreted by astrocytes, is recognized as a biomarker of neural distress.

This study aimed to investigate the relationship between antenatal MgSO4 administration and umbilical cord serum S100B levels, with a focus on gestational age.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

This retrospective study included women who delivered between 22+0 and 33+6 weeks of gestation at a tertiary center.

Patients with hypertensive disorders of pregnancy, category 1 cesarean sections, multiple pregnancies, major congenital anomalies, or insufficient MgSO4 administration were excluded.

How the Study Was Run

Cord blood samples were analyzed for S100B levels using ELISA.

What Was Measured

Topics PubMed links to this paper include Magnesium Sulfate, S100 Calcium Binding Protein beta Subunit, Fetal Blood, Gestational Age, Premature Birth, Neuroprotective Agents and Biomarkers.

Author keywords: S100B, fetal neuroprotection, preterm birth and umbilical cord blood.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (The journal of obstetrics and gynaecology research), a journal based in Australia.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.