Comparative Effectiveness of Recombinant Human Follicle-Stimulating Hormone:Recombinant Human Luteinizing Hormone in a 2:1 Ratio versus Highly Purified Human Menopausal Gonadotropin Alone in Ovarian Stimulation for Medically Assisted Reproduction Treatment Using in vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis.

What It Covers

The paper reports a study of HMG (Human Menopausal Gonadotropin), published as a meta-analysis.

A systematic review and meta-analysis of published evidence was performed to compare the number of oocytes retrieved with recombinant human follicle-stimulating hormone:recombinant human luteinizing hormone (r-hFSH:r-hLH) in a 2:1 ratio versus highly purified human menopausal gonadotropin (HP-hMG) alone from day 1 of OS.

Who the Included Studies Covered

PubMed tags the participants as women only.

The literature search was conducted according to PRISMA guidelines (<ext-link ext-link-type="uri" xlink:href="https://www.prisma-statement.org/" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.prisma-statement.org/</ext-link>) using Medline, EMBASE, Biosis, SciSearch, and TOXCENTER on STN.

How the Review Was Done

Studies were included if they reported on r-hFSH:r-hLH in a 2:1 ratio versus HP-hMG alone, both administered from day 1 of OS, and the results for the number of oocytes retrieved were presented for both interventions.

Data were extracted from the full articles independently by two reviewers (J.-E.S. and B.H.).

Results were analyzed using a random-effects meta-analysis model.

Any potential risk of bias was assessed using the ROBINS-I tool.

Secondary outcomes were the number of mature (MII) oocytes, clinical pregnancy rate, ongoing pregnancy rate, and live birth rate.

What Was Measured

Topics PubMed links to this paper include Ovulation Induction, Menotropins, Luteinizing Hormone, Recombinant Proteins, Sperm Injections, Intracytoplasmic, Fertilization in Vitro and Follicle Stimulating Hormone, Human.

The authors tagged it with the keywords Clinical pregnancy rate, Highly purified human menopausal gonadotropin, Meta-analysis, Oocyte number, Recombinant human follicle-stimulating hormone and Recombinant human luteinizing hormone.

What This Means in Plain Language

This is a meta-analysis of HMG (Human Menopausal Gonadotropin).

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (Gynecologic and obstetric investigation), a journal based in Switzerland.

More context: the HMG (Human Menopausal Gonadotropin) compound page, all human trials.