Clinical evaluation of composite restorations placed on dimethyl sulfoxide-treated cervical carious lesions: a 36-month randomized double-blind controlled trial

What Was Tested

The paper reports a study of DMSO (dimethyl sulfoxide, non-peptide solvent), published as a randomized controlled trial.

To evaluate the effect of a novel restorative approach using dimethyl sulfoxide (DMSO) as a cavity pretreatment on the material fracture and retention (primary outcome) of direct composite fillings placed on cervical carious lesions (CCLs).

Who Took Part

According to the abstract, 45 patients were involved.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

45 patients presenting CCLs were screened and randomized into two groups containing 37 caries lesions/group: an untreated control (20 patients) and a DMSO-treated (25 patients) group.

After baseline assessments (7 days), fillings were evaluated at 12-, 24- and 36-month follow-ups according to the FDI criteria (fracture/retention, marginal staining, marginal adaptation, postoperative sensitivity and caries recurrence).

How the Study Was Run

In design terms this was a randomized, double-blind and parallel-group study.

Because people in this DMSO (dimethyl sulfoxide, non-peptide solvent) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on DMSO (dimethyl sulfoxide, non-peptide solvent), so expectations could not easily colour the readings.

Groups ran in parallel: each of the patients stayed in one arm throughout.

Following a parallel-study design, two calibrated operators placed 74 (n = 37) composite fillings (Filtek Z350XT, 3 M ESPE) using a 2-step etch-and-rinse adhesive (Single Bond 2, 3 M ESPE).

For statistical analysis, Chi-Square and Cochran's Q tests were used (α = 0.05) following the Bonferroni correction.

What Was Measured

Topics PubMed links to this paper include Dimethyl Sulfoxide, Dental Caries, Dental Restoration, Permanent, Composite Resins, Dental Marginal Adaptation, Tooth Cervix and Dental Restoration Failure.

The authors tagged it with the keywords Adhesive, Bond, Carious cervical, Clinical trial, DMSO and Primer.

What This Means in Plain Language

The paper is a randomized, double-blind and parallel-group study of DMSO (dimethyl sulfoxide, non-peptide solvent) in 45 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (Journal of dentistry), a journal based in England.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.