Plasma vitamin D and cytokines in relation to exercise in patients with fibromyalgia- A 15-week strength training intervention trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The mechanisms involved in the associations of fibromyalgia to vitamin D, biomarkers of inflammation and their relation to exercise have not been reported previously.

This study aimed to investigate the effects of exercise on plasma 25-hydroxyvitamin D3 levels in patients with fibromyalgia, and further to examine the associations between biomarkers of chronic inflammation and vitamin D status.

Who Took Part

The age groups tagged for this paper are young adults, adults, middle-aged adults and older adults, women only.

Women with fibromyalgia (n=84) aged 20-65 years and 36 age-matched healthy controls were included.

The fibromyalgia patients were randomised to resistance exercise or relaxation therapy and were examined based on physical capacity, symptoms and biomarkers including plasma 25-hydroxyvitamin D3 and cytokines.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

This is a sub-study of a larger randomised controlled multi-center trial.

What Was Measured

Topics PubMed links to this paper include Fibromyalgia, Cytokines, Resistance Training, Vitamin D, Biomarkers and Calcifediol.

The authors tagged it with the keywords exercise.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (Scandinavian journal of pain), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.