The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Vitamin K2 supplementation has emerged as a strategy to enhance recovery and modulate postexercise physiological responses.

This study aimed to assess the effects of vitamin K2 on recovery from muscle-damaging exercise in young and older adults.

Who Took Part

The age groups tagged for this paper are teenagers, young adults, adults and older adults, both men and women.

Before and after supplementation, knee extensor maximal torque, functional ability, muscle soreness, and systemic blood markers of muscle damage and inflammation were measured before (0 h) and 3, 24, 48, and 72-h postexercise.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Data were analyzed using regression and mixed models.

What Was Measured

Topics PubMed links to this paper include Vitamin K 2, Resistance Training, Post-Exercise Recovery, Myalgia, Muscle, Skeletal, Dietary Supplements and Interleukin-6.

The authors tagged it with the keywords INFLAMMATION, MUSCLE DAMAGE, RESISTANCE EXERCISE and VITAMIN K2.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (Medicine and science in sports and exercise), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.