Is urinary myelin basic protein the key to understanding the role of vitamin D supplementation in paediatric overactive bladder-dry? Results from a three-stage clinical investigation.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

To validate urinary myelin basic protein (uMBP) as a mechanism-based diagnostic and prognostic biomarker for paediatric overactive bladder-dry (OAB-dry) in children with 25-hydroxyvitamin D (25[OH]D) levels of <35 ng/mL, and to explore whether vitamin D supplementation (VDS) targets a reversible neuromyelination pathway.

Who Took Part

By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.

How the Study Was Run

The researchers set it up as a randomized and multicenter study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

More than one site took part, so the participants came from several places.

This three-phase study comprised: (i) discovery of candidate biomarkers via urinary proteomics; (ii) diagnostic validation in a cross-sectional cohort (n = 216); and (iii) a 12-week multicentre randomised controlled trial (RCT, n = 180).

What Was Measured

Topics PubMed links to this paper include Urinary Bladder, Overactive, Vitamin D, Biomarkers, Myelin Basic Protein, Cross-Sectional Studies and Dietary Supplements.

The authors tagged it with the keywords overactive bladder and paediatrics.

What This Means in Plain Language

The paper is a randomized and multicenter study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (BJU international), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.