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Effects of vitamin D deficiency and supplementation on myocardial and hepatic iron status and function in children with beta-thalassemia.
Plain-language guide to PMID 41979683 (2026): observational study of Vitamin D, K2, Magnesium and Zinc in 88 patients.
Key Facts
- PMID
- 41979683
- Journal
- Annals of hematology
- Year
- 2026
- Study type
- Observational Study
- Authors
- Solğun HA et al. (2 authors)
- DOI
- 10.1007/s00277-026-06978-2
What This Study Did, in Plain Language
What Was Tested
This observational study looks at Vitamin D, K2, Magnesium and Zinc.
BACKGROUND: This study aimed to evaluate the prevalence of vitamin D deficiency and to assess the effects of vitamin D supplementation on myocardial and hepatic iron burden and organ function in children with transfusion-dependent beta-thalassemia (TDT).
Why It Was Studied
METHODS: A cross-sectional observational study was conducted in the pediatric hematology department of their institution.
Baseline and post-treatment laboratory assessments included serum calcium, phosphate, alkaline phosphatase, parathyroid hormone (PTH), and 25-hydroxyvitamin D [25(OH)D] levels.
Who Took Part
The abstract describes 88 patients taking part.
By PubMed's age tags, the people studied were young children, children, teenagers and young adults, both men and women.
Patients aged three years and older with transfusion-dependent beta-thalassemia were included.
RESULTS: A total of 88 pediatric patients were enrolled.
How the Study Was Run
Cardiac and hepatic iron deposition were evaluated using T2* magnetic resonance imaging (MRI), and left ventricular ejection fraction (LVEF) was assessed by echocardiography.
What Was Measured
Baseline and post-treatment laboratory assessments included serum calcium, phosphate, alkaline phosphatase, parathyroid hormone (PTH), and 25-hydroxyvitamin D [25(OH)D] levels.
PubMed files the paper under topics including beta-Thalassemia, Vitamin D Deficiency, Cross-Sectional Studies, Liver, Dietary Supplements, Vitamin D and Myocardium.
The authors tagged it with the keywords 25-hydroxyvitamin D, Cardiac, Iron overload, MRI T2*, Pediatrics and Transfusion-dependent.
What This Means in Plain Language
This is an observational study of Vitamin D, K2, Magnesium and Zinc in 88 patients.
The publication is from 2026 (Annals of hematology), a journal based in Germany.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.