Effect of vitamin D supplementation on metabolic syndrome and atherosclerosis biomarkers in epilepsy: a randomized controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To analyze the effect of vitamin D administration on serum 25(OH)D levels and biomarkers of metabolic syndrome and atherosclerosis (homeostatic model assessment of insulin resistance [HOMA-IR], adiponectin, homocysteine, and high sensitivity C-reactive protein [hs-CRP]) in epilepsy patients receiving enzymatic antiseizure medications (ASMs).

Who Took Part

The study group was 40 patients.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

The primary outcome was the change in serum 25-hydroxyvitamin D (25[OH]D) levels.

Secondary outcomes included changes in HOMA-IR, adiponectin, homocysteine, and hs-CRP.

Data were analyzed using a per-protocol approach.

What Was Measured

The subject headings attached to it are Biomarkers, Epilepsy, Vitamin D, Metabolic Syndrome, C-Reactive Protein, Atherosclerosis and Dietary Supplements.

Author keywords: anticonvulsants, cholecalciferol and insulin resistance.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 40 patients.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina), a journal based in Bosnia and Herzegovina.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.