Effects of a Mixed Herbal and Fruit Dietary Supplement Shot on Antioxidant Status, Oxidative Stress Parameters, Skin Parameters, and Safety Profiles in Middle-Aged Women: A Randomized, Double-Blind, Placebo-Controlled Trial.

What Was Tested

Researchers studied Copper (Supplement) in this randomized controlled trial publication.

Middle-aged women experience hormonal fluctuations and reproductive transitions that accelerate menopausal symptoms, tissue degeneration, and skin aging due to an imbalance between antioxidant defenses and reactive oxygen species.

Enhancing antioxidant defenses may mitigate oxidative stress and maintain skin health.

Who Took Part

The abstract describes 30 participants taking part.

By PubMed's age tags, the people studied were middle-aged adults, women only.

In this 12-wk randomized, double-blind, placebo-controlled trial, 30 participants received either HERB or placebo (PLA).

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

As a double-blind Copper (Supplement) study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.

Primary outcomes were antioxidant status and oxidative stress parameters.

Skin parameters and safety profiles were also assessed.

Data were analyzed using intention-to-treat and per-protocol approaches.

Between-group comparisons were conducted using analysis of covariance adjusted for baseline or Student's t-tests.

What Was Measured

PubMed files the paper under topics including Oxidative Stress, Antioxidants, Fruit, Dietary Supplements, Superoxide Dismutase, Skin and Skin Aging.

Author keywords: skin health and women.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 30 participants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 11 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (The Journal of nutrition), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.