← Human Trials & Peer-Reviewed Studies
Effectiveness of a Comprehensive Program Including a Novel Concentrated High-Protein, High-Calorie Oral Nutritional Supplement to Enhance Nutritional and Morphofunctional Recovery in Malnourished Patients with Cancer: The ONAVIDA Study.
Plain-language guide to PMID 42123999 (2026): multicenter observational study of Copper (Supplement).
Key Facts
- PMID
- 42123999
- Journal
- Nutrients
- Year
- 2026
- Study type
- Observational Study
- Authors
- García-Almeida JM et al. (19 authors)
- DOI
- 10.3390/nu18091398
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Copper (Supplement), published as an observational study.
Malnutrition in cancer adversely affects treatment outcomes and survival.
Why It Was Studied
Observational design, no control group, short follow-up, and unadjusted non-multivariable comparisons, limiting causal inference.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
Two hundred thirty malnourished patients with cancer were enrolled: 147 naïve (no ONS treatment in the last three months) and 83 non-naïve (who transitioned to cHPHC-ONS after inadequate response to initial ONSs).
Nutritional status was assessed using Global Leadership Initiative on Malnutrition (GLIM) criteria and morphofunctional parameters via bioelectrical impedance analysis, nutritional ultrasound, handgrip strength, the Timed Up and Go (TUG) test, and analysis of biochemical parameters.
How the Study Was Run
In design terms this was a multicenter study.
More than one site took part, so the participants came from several places.
A prospective, observational, multicenter cohort study was conducted across 18 public hospitals in Spain.
What Was Measured
PubMed files the paper under topics including Malnutrition, Dietary Supplements, Neoplasms, Nutritional Status, Spain, Energy Intake and Hand Strength.
Author keywords: bioelectrical impedance, cancer, morphofunctional assessment, novel concentrated oral nutritional supplement and nutritional ultrasound.
What This Means in Plain Language
The paper is a multicenter study of Copper (Supplement).
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2026 (Nutrients), a journal based in Switzerland.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.