Exploratory pilot trial of a multicomponent immunonutritional supplement in children with allergic asthma and rhinitis: The INAPRA study.

What Was Tested

Researchers studied Copper (Supplement) in this randomized controlled trial publication.

To explore the clinical and immunomodulatory potential of a multicomponent immunonutritional supplement containing postbiotics in children with concomitant allergic asthma and AR.

Why It Was Studied

Allergic asthma and allergic rhinitis (AR) are among the most frequent chronic conditions in the pediatric age.

They frequently coexist in children and are sustained by type 2- driven airway inflammation and impaired epithelial-immune interactions.

Who Took Part

The age groups tagged for this paper are young children and children, both men and women.

Co-primary outcomes were changes in respiratory symptom control assessed by Childhood Asthma Control Test (c-ACT), CARATkids, and Total Nasal Symptom Score (TNSS).

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled, multicenter and pilot.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Copper (Supplement).

The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.

Running at several centres spread the Copper (Supplement) study over different clinics and patient groups.

The ImmuneNutrition Against Pediatric Respiratory Allergies (INAPRA) study was a multicenter, randomized, double-blind, placebo-controlled exploratory pilot trial.

Secondary outcomes included cytokine production, regulatory T-cell rate and tolerogenic gene expression (gfb1, Ptgs2, Csf2, and Ifna2) in peripheral blood mononuclear cells (PBMCs).

Immunological assays were performed in vitro on PBMCs collected before intervention.

What Was Measured

The subject headings attached to it are Pilot Projects, Asthma, Rhinitis, Allergic, Dietary Supplements, Cytokines, Immunonutrition Diet and Dermatophagoides pteronyssinus.

Author keywords: Allergic asthma, Allergic rhinitis, L. rhamnosus GG, Pediatric allergy, Perilla frutescens and Postbiotics.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (International immunopharmacology), a journal based in Netherlands.

More context: the Copper (Supplement) compound page, all human trials.