Effect of NSAIDs, melatonin, vitamin D and vitamin B12 chronotherapy on postoperative recovery after third molar surgical extraction: A pilot randomized crossover placebo-controlled trial

What Was Tested

This randomized controlled trial paper looks at Cyanocobalamin (Vitamin B12) in the context of post-surgical inflammation and surgery recovery.

ClinicalTrials.gov (NCT07133360), retrospectively registered on 2025/06/20.

Who Took Part

According to the abstract, 12 adults were involved.

By PubMed's age tags, the people studied were adults, both men and women.

A double-blind, randomized, two-period pilot crossover trial was conducted with 12 healthy adults undergoing bilateral mandibular third molars extraction.

How the Study Was Run

In design terms this was a randomized, double-blind, crossover and pilot study.

The adults were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.

Blinding on both sides kept the adults and researchers unaware of who received Cyanocobalamin (Vitamin B12).

Each person switched between Cyanocobalamin (Vitamin B12) and the comparison at some point, usually with a gap in between.

It is described as a pilot, a small early test of whether a larger Cyanocobalamin (Vitamin B12) study would be practical.

Outcomes included pain intensity (Visual Analogue Scale [VAS]), facial swelling, trismus, rescue medication use, and inflammatory cytokines.

What Was Measured

Topics PubMed links to this paper include Molar, Third, Tooth Extraction, Pilot Projects, Melatonin, Postoperative Pain, Anti-Inflammatory Agents, Non-Steroidal and Vitamin B 12.

Author keywords: Chronotherapy, Circadian rhythm, Postoperative complications, Postoperative recovery and Third molar extraction.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of Cyanocobalamin (Vitamin B12) in 12 adults in people with post-surgical inflammation and surgery recovery.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (Oral and maxillofacial surgery), a journal based in Germany.

More context: the Cyanocobalamin (Vitamin B12) compound page, Post-surgical inflammation and surgery recovery research.