Vitamin D in Alzheimer's disease: Neuroinflammatory, metabolic, and clinical implications.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a review.

BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide.

Beyond amyloid-β and tau pathology, accumulating evidence indicates that chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, disrupted calcium homeostasis, and diabetes are critically contributing to disease onset and progression, underscoring the need to identify modulatory factors that influence multiple pathogenic pathways.ObjectiveThis review evaluates the role of vitamin D in modulating cognitive function and its association with the pathophysiology of AD.MethodsThis narrative review examines the connection between vitamin D and cognitive and neurological outcomes by integrating findings from preclinical and clinical studies.

What Was Measured

Beyond amyloid-β and tau pathology, accumulating evidence indicates that chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, disrupted calcium homeostasis, and diabetes are critically contributing to disease onset and progression, underscoring the need to identify modulatory factors that influence multiple pathogenic pathways.ObjectiveThis review evaluates the role of vitamin D in modulating cognitive function and its association with the pathophysiology of AD.MethodsThis narrative review examines the connection between vitamin D and cognitive and neurological outcomes by integrating findings from preclinical and clinical studies.

PubMed files the paper under topics including Alzheimer Disease, Vitamin D, Neuroinflammatory Diseases, Vitamin D Deficiency, Brain and Oxidative Stress.

The authors tagged it with the keywords Alzheimer’s disease, amyloid-β, neuroinflammation and vitamin D receptor.

What This Means in Plain Language

This is a review of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2026 (Journal of Alzheimer's disease : JAD), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.