The Serum 25-Hydroxyvitamin D Response to Supplemental Vitamin D Is Temporarily Blunted with Elevated Circulating Cytokines at Baseline.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

This secondary analysis combined data from separate randomized, double-blind, placebo-controlled studies consisting of reportedly healthy adults and individuals with knee osteoarthritis who received supplemental vitamin D.

Subjects were separated into 2 groups based on serum IL-6 concentrations at baseline (Bsl; prior to supplemental vitamin D): (1) non-elevated IL-6 (<2.5 pg/mL; n = 22) or (2) elevated IL-6 (≥2.5 pg/mL; n = 11).

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

What Was Measured

This secondary analysis combined data from separate randomized, double-blind, placebo-controlled studies consisting of reportedly healthy adults and individuals with knee osteoarthritis who received supplemental vitamin D.

PubMed files the paper under topics including Vitamin D, Cytokines, Dietary Supplements, Osteoarthritis, Knee and Interleukin-6.

Author keywords: serum 25-hydroxyvitamin D and serum interleukin-6.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2026 (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.