Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To evaluate the effects of magnesium supplementation as an adjunct to fluoxetine on serum brain-derived neurotrophic factor (BDNF) levels and cognitive function in patients with depression.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults and middle-aged adults, both men and women.

Outpatients aged 18 to 50 years diagnosed with depression who were receiving fluoxetine treatment at various hospitals in Makassar, Indonesia, between July and August 2025 were invited to participate.

Patients were assessed at baseline and 6 weeks.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

BDNF levels were measured using peripheral venous blood samples.

Serum BDNF concentrations (in pg/mL) were quantified using an enzyme-linked immunosorbent assay kit.

Cognitive function was assessed using the validated Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina).

What Was Measured

The subject headings attached to it are Fluoxetine, Brain-Derived Neurotrophic Factor, Magnesium, Cognition, Dietary Supplements, Indonesia and Cognitive Enhancement.

The authors tagged it with the keywords Major depressive disorder.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan), a journal based in China.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.