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Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial
Plain-language guide to PMID 42393020 (2026): randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 153 adults, anemia.
Key Facts
- PMID
- 42393020
- Journal
- American journal of hematology
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- Singh SK et al. (10 authors)
- DOI
- 10.1002/ajh.70433
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in the context of anemia in this randomized controlled trial publication.
The researchers thus aimed to compare intranasal, intramuscular, and intravenous vitamin B12 therapy for hematological recovery in vitamin B12 deficiency anemia, and to identify independent predictors of treatment response.
Why It Was Studied
Inter-group comparisons used the Kruskal-Wallis test; covariate-adjusted analyzes employed ANCOVA and multiple linear regression.
Who Took Part
According to the abstract, 153 adults were involved.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
In this prospective randomized controlled trial (IEC/2024/450; CTRI/2024/10/075521), 153 adults with vitamin B12 deficiency were randomized to intranasal (n = 55), intravenous (n = 56), or intramuscular (n = 42) administration.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
Hemoglobin (Hb), mean corpuscular volume (MCV), reticulocyte count, and lactate dehydrogenase (LDH) were assessed at baseline and on Days 7, 14, and 28.
What Was Measured
Inter-group comparisons used the Kruskal-Wallis test; covariate-adjusted analyzes employed ANCOVA and multiple linear regression.
The subject headings attached to it are Vitamin B 12 Deficiency, Vitamin B 12, Hemoglobins, Reticulocyte Count, L-Lactate Dehydrogenase, Administration, Intravenous and Erythrocyte Indices.
The authors tagged it with the keywords intramuscular cyanocobalamin, intranasal cobalamin, intravenous cyanocobalamin, megaloblastic anemia, randomized controlled trial and vitamin B12 deficiency.
What This Means in Plain Language
The paper is a randomized study of Cyanocobalamin (Vitamin B12) in 153 adults in people with anemia.
The publication is from 2026 (American journal of hematology), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, Anemia research.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.