← Human Trials & Peer-Reviewed Studies
Synergistic pain relief in cervical radiculopathy: A randomized trial of topical methylcobalamin gel with phonophoresis and Mulligan mobilization.
Plain-language guide to PMID 42393386 (2026): single-blind randomized controlled trial of Cyanocobalamin (Vitamin B12).
Key Facts
- PMID
- 42393386
- Journal
- Acta neurologica Belgica
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- Khan IA et al. (4 authors)
- DOI
- 10.1007/s13760-026-03128-3
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
Cervical radiculopathy is a neuropathic disorder caused by nerve root compression that presents as pain that refers to the upper limb, numbness, and weakness.
Why It Was Studied
Iranian registry of clinical trial IRCT20241220064105N2.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
A single-blinded, randomized clinical trial was conducted in Pakistan between November 2024 and April 2025, involving 370 (consented) patients with cervical radiculopathy.
Patients were randomly divided into two groups: Group A received treatment of MeCbl gel, along with phonophoresis plus Mulligan traction and mobilization, whereas Group B received Mulligan traction and mobilization with topical MeCbl gel without phonophoresis.
How the Study Was Run
In design terms this was a randomized and single-blind study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
Only one side, usually the participants, was kept unaware of whether Cyanocobalamin (Vitamin B12) was given.
Outcomes were measured using the validated 0-10 Numerical Pain Rating Scale (NPRS), a measure of pain intensity, and the Neck Disability Index (NDI), which measures cervical functional impairment on a scale from 0 to 50.
What Was Measured
PubMed files the paper under topics including Radiculopathy, Phonophoresis, Gels, Pain Management, Pain Measurement, Traction and Combined Modality Therapy.
Author keywords: Cervical radiculopathy and Methycobalmine gel.
What This Means in Plain Language
The paper is a randomized and single-blind study of Cyanocobalamin (Vitamin B12).
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2026 (Acta neurologica Belgica), a journal based in Italy.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.