Umbrella review of photobiomodulation/low-level laser therapy and vitamin D in orthodontics: effects on tooth movement, pain, root resorption, and bone biomarkers.

What It Covers

This systematic review looks at Vitamin D, K2, Magnesium and Zinc.

To synthesize evidence from systematic reviews and meta-analyses on low-level laser therapy/Photobiomodulation (LLLT/PBM) and vitamin D as non-invasive adjuncts for accelerating orthodontic tooth movement (OTM) and mitigating associated side effects.

How the Review Was Done

PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases were searched from inception to November 18, 2025.

SRMAs primarily comprising human RCTs evaluating LLLT/PBM or vitamin D in orthodontics were included; in some mixed-design reviews, clearly separable human orthodontic data from a small number of CCTs were retained narratively.

(one pre-registered exception with 4 RCTs for vitamin D to ensure completeness).

Randomized controlled trials were prioritized; some retained reviews also included a small number of controlled clinical trials when relevant human orthodontic data were clearly separable.

Quality was assessed using AMSTAR-2, ROBIS, and GRADE.

What Was Measured

To synthesize evidence from systematic reviews and meta-analyses on low-level laser therapy/Photobiomodulation (LLLT/PBM) and vitamin D as non-invasive adjuncts for accelerating orthodontic tooth movement (OTM) and mitigating associated side effects.

Topics PubMed links to this paper include Tooth Movement Techniques, Low-Level Light Therapy, Vitamin D, Root Resorption, Biomarkers and Orthodontics.

The authors tagged it with the keywords Low-level laser therapy, Orthodontic tooth movement, Photobiomodulation and Umbrella review.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (BMC oral health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.