Efficacy of magnesium-calcium ionic oral rinse for primary burning mouth syndrome: a randomized, double-blind, placebo-controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Primary burning mouth syndrome (BMS) is a chronic idiopathic orofacial pain condition characterized by persistent intraoral burning sensation in the absence of clinically evident mucosal lesions.

Its pathophysiology is considered multifactorial, with neuropathic mechanisms playing a central role.

Who Took Part

The study group was 116 adults.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The adults were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The primary outcome was change in burning pain intensity assessed using a Numeric Rating Scale (NRS).

What Was Measured

Primary burning mouth syndrome (BMS) is a chronic idiopathic orofacial pain condition characterized by persistent intraoral burning sensation in the absence of clinically evident mucosal lesions.

Topics PubMed links to this paper include Burning Mouth Syndrome, Mouthwashes, Magnesium, Calcium and Pain Measurement.

The authors tagged it with the keywords Calcium chloride, Magnesium chloride, Neuropathic pain, Oral rinse, Randomized trial and Theravex Technology, THERAVEX® Total Oral Care Plus.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 116 adults.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (BMC oral health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.