The impact of vitamin D supplementation on depression and anxiety in young individuals with depression and vitamin D insufficiency/deficiency.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

This study evaluates the effects of vitamin D supplementation on depression and anxiety in young people with major depression and vitamin D insufficiency/deficiency.

Who Took Part

PubMed indexes the participants as children, teenagers and young adults, both men and women.

This partially randomized patient preference trial enrolled outpatients aged 10-24 with major depression and vitamin D insufficiency/deficiency.

Participants who expressed a preference received vitamin D, while others were randomly assigned to vitamin D or placebo groups.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Randomization was performed using computer-generated random numbers in blocks of four, with allocation concealed from researchers, participants, and treating physicians.

The primary outcome was assessor-rated depressive symptoms measured using the 17-item Hamilton Depression Rating Scale.

Secondary outcomes were self-reported depression (Beck Depression Inventory-II) and anxiety (Generalized Anxiety Disorder-7).

What Was Measured

PubMed files the paper under topics including Vitamin D Deficiency, Dietary Supplements, Anxiety, Vitamin D, Depression, Cholecalciferol and Major Depressive Disorder.

Author keywords: Adolescents, Supplementation and Young individuals.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.