Periconception Maternal-Serum Vitamin D, Vaginal Bleeding, and Subchorionic Hemorrhage in Early Pregnancy.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Background/Objectives: To examine relationships between maternal-serum 25(OH)D levels at preconception and 8 weeks' gestation and the risk of vaginal bleeding and subchorionic hemorrhage during pregnancy.

Why It Was Studied

Methods: A secondary analysis of the EAGeR Trial, which is a prospective, multisite, randomized controlled trial that enrolled 1228 women with 1-2 prior pregnancy losses.

Analyses were restricted to participants who became pregnant and had 25(OH)D measured at preconception (n = 747) and 8 weeks' gestation (n = 605).

Who Took Part

According to the abstract, 1228 women were involved.

The age groups tagged for this paper are young adults and adults, women only.

How the Study Was Run

The design is described as randomized.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Vaginal bleeding and subchorionic hemorrhage were assessed via medical record extraction, which captured clinically recognized symptoms at medical visits measured at any point throughout pregnancy.

What Was Measured

Methods: A secondary analysis of the EAGeR Trial, which is a prospective, multisite, randomized controlled trial that enrolled 1228 women with 1-2 prior pregnancy losses.

Analyses were restricted to participants who became pregnant and had 25(OH)D measured at preconception (n = 747) and 8 weeks' gestation (n = 605).

Topics PubMed links to this paper include Uterine Hemorrhage, Vitamin D, Pregnancy Complications, Vitamin D Deficiency, Risk Factors, Pregnancy Trimester, First and Logistic Models.

Author keywords: preconception, subchorionic hemorrhage and vaginal bleeding.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 1228 women.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 2026 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.