Vitamin D Supplementation and 12-Month Changes in Muscle Function and Physical Performance in Older Adults with Vitamin D Deficiency: A Prospective Observational Cohort Study.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

Vitamin D deficiency in older adults may impair muscle function and physical performance.

This prospective observational cohort study examined the 12-month outcomes of vitamin D supplementation, delivered as part of routine clinical care, in older adults with vitamin D deficiency compared with an insufficiency comparison group.

Who Took Part

The study group was 194 participants.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

A total of 194 participants aged ≥60 years were enrolled: 164 with vitamin D deficiency (25(OH)D <20 ng/mL; supplementation group) and 30 with insufficiency (20-29 ng/mL; comparison group).

The supplementation group received supplementation targeting 25(OH)D >30 ng/mL; the comparison group received no supplementation.

How the Study Was Run

The Handgrip Strength Test (HGS), the Gait Speed Test (GST), the Short Physical Performance Battery Test (SPPB), and the Timed Up and Go Test (TUG) were assessed at baseline and 12 months.

What Was Measured

This prospective observational cohort study examined the 12-month outcomes of vitamin D supplementation, delivered as part of routine clinical care, in older adults with vitamin D deficiency compared with an insufficiency comparison group.

Topics PubMed links to this paper include Dietary Supplements, Hand Strength, Muscle, Skeletal, Physical Functional Performance, Vitamin D, Vitamin D Deficiency and Cohort Studies.

The authors tagged it with the keywords functional decline, handgrip strength, muscle function, musculoskeletal health, older adults and physical performance.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 194 participants.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.