DHA Alone, EPA + DHA, EPA + DHA + GLA, and EPA + DHA with or Without Vitamin D During Chemotherapy in Women with Breast Cancer: An Intervention- and Outcome-Stratified Systematic Review.

What It Covers

This systematic review looks at Vitamin D, K2, Magnesium and Zinc.

The researchers summarized and critically appraised interventions comprising DHA alone, EPA + DHA, EPA + DHA + GLA, or EPA + DHA with or without vitamin D, stratified by intervention composition and outcome domain.

Methods: PubMed/MEDLINE, the Cochrane Library/CENTRAL, ClinicalTrials.gov, Scopus, Web of Science Core Collection, and Embase were last searched on 8 July 2026, supplemented by citation searching.

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

Owing to clinical and methodological heterogeneity, findings were synthesized narratively; risk of bias and outcome-specific certainty were assessed using RoB 2-informed and GRADE approaches.

Results: Fourteen reports representing ten prospective interventional trials were included.

What Was Measured

The researchers summarized and critically appraised interventions comprising DHA alone, EPA + DHA, EPA + DHA + GLA, or EPA + DHA with or without vitamin D, stratified by intervention composition and outcome domain.

Eligible studies prospectively administered EPA and/or DHA during chemotherapy and reported inflammatory/biological, nutritional/functional, quality-of-life, treatment-related, anticancer-response, or safety outcomes.

Topics PubMed links to this paper include Breast Neoplasms, Docosahexaenoic Acids, Vitamin D, Eicosapentaenoic Acid, Dietary Supplements, gamma-Linolenic Acid and Quality of Life.

The authors tagged it with the keywords GRADE, breast cancer, chemotherapy, inflammation, nutritional status and omega-3 fatty acids.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2026 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.