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Vitamin D Supplementation and its Effect on Relapse Frequency and MRI Activity in Adults With Multiple Sclerosis: A Systematic Review.
Plain-language guide to PMID 42613863 (2026): systematic review of Vitamin D, K2, Magnesium and Zinc, multiple sclerosis.
Key Facts
- PMID
- 42613863
- Journal
- Brain and behavior
- Year
- 2026
- Study type
- Systematic Review
- Authors
- Hall K et al. (5 authors)
- DOI
- 10.1002/brb3.71692
What This Paper Covers, in Plain Language
What It Covers
This systematic review looks at Vitamin D, K2, Magnesium and Zinc in the context of multiple sclerosis.
Thus, this systematic review aimed to evaluate the effect of vitamin D supplementation on relapse rate and magnetic resonance imaging (MRI) disease activity in adults with clinically diagnosed MS.
Why It Was Studied
Literature evidence links vitamin D supplementation to clinical outcomes in multiple sclerosis (MS), yet no systematic review has focused specifically on relapse rate and MRI activity.
Who the Included Studies Covered
The age groups tagged for this paper are adults.
PubMed, Cochrane, EBSCO, and Web of Science were searched for studies discussing vitamin D supplementation in adults with diagnosed MS.
How the Review Was Done
This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.
Annualized relapse rate (ARR) and changes in MRI activity were the primary outcome measures.
Non-randomized studies and randomized controlled trials were assessed for their risk of bias using the Cochrane ROBINS-I and RoB-2 tools, respectively.
What Was Measured
Literature evidence links vitamin D supplementation to clinical outcomes in multiple sclerosis (MS), yet no systematic review has focused specifically on relapse rate and MRI activity.
The subject headings attached to it are Magnetic Resonance Imaging, Vitamin D, Dietary Supplements, Multiple Sclerosis and Recurrence.
Author keywords: MRI and relapse rate.
What This Means in Plain Language
This is a systematic review of Vitamin D, K2, Magnesium and Zinc in people with multiple sclerosis.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2026 (Brain and behavior), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Multiple sclerosis research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.