Growth hormone deficiency: craniofacial characteristics and changes after growth hormone therapy - a systematic review.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this systematic review publication.

This systematic review aimed to compile evidence from January 2000 to April 2026 regarding the craniofacial features of children and adolescents with non-syndromic GHD, as well as the craniofacial changes observed during GHT.

Why It Was Studied

Growth hormone deficiency (GHD) is among the most common pituitary hormone disorders in children, causing impaired growth in children and may also affect craniofacial and dental development.

Growth hormone therapy (GHT) is the main course of treatment.

Who the Included Studies Covered

By PubMed's age tags, the people studied were children and teenagers.

PubMed, Google Scholar and Scopus were searched for studies published from 2000 to April 2026 that assessed craniofacial or dental changes in non-syndromic GHD patients undergoing GHT.

How the Review Was Done

Two reviewers screened the studies and assessed risk of bias using the AXIS tool and the Newcastle-Ottawa Scale.

Owing to methodological and clinical heterogeneity, a meta-analysis was not performed.

What Was Measured

Topics PubMed links to this paper include Human Growth Hormone, Maxillofacial Development and Craniofacial Abnormalities.

Author keywords: Craniofacial morphology, Dental maturation, Dentofacial growth, Growth hormone deficiency and Growth hormone therapy.

What This Means in Plain Language

This is a systematic review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (Endocrine), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.