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Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial.

Plain-language guide to PMID 42829807 (2026): double-blind randomized controlled trial of Copper (Supplement) in 103 adults.

Key Facts

PMID
42829807
Journal
Journal of the International Society of Sports Nutrition
Year
2026
Study type
Randomized Controlled Trial
Authors
Mastrofini GF et al. (11 authors)
DOI
10.1080/15502783.2026.2740227

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Copper (Supplement), published as a randomized controlled trial.

Therefore, this study evaluated the impact of morning adaptogens, evening sleep-focused supplements, and their combination on stress, mood, and subjective and objective sleep quality.

Who Took Part

The abstract describes 103 adults taking part.

PubMed indexes the participants as young adults, adults and middle-aged adults, both men and women.

The total study duration was four weeks, consisting of one baseline week, two weeks of supplementation, and one washout week.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The adults were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

Neither the adults nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.

Data were analyzed using baseline-adjusted linear mixed-effects models with alpha set at 0.05.

Tukey-adjusted post hoc comparisons were performed, and effect sizes are reported as partial eta squared (η2) and Cohen's d (d).

What Was Measured

Topics PubMed links to this paper include Dietary Supplements, Stress, Psychological, Affect, Sleep Quality, Sleep, Sleep Duration and Subjective Stress.

Author keywords: Adaptogens, mood, perceived stress and sleep disturbance.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 103 adults.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (Journal of the International Society of Sports Nutrition), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.

Our Notes on the Compound

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.