Vitamin D status and adiposity in children with low-energy fractures: a prospective case-control study

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this observational study publication.

Fractures in children are influenced by both skeletal biology and mechanical factors.

While alterations in vitamin D and other metabolic markers have been proposed as contributors to fracture risk, their role in predicting fractures in otherwise healthy pediatric populations remains unclear.

Who Took Part

According to the abstract, 100 children were involved.

By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.

How the Study Was Run

Associations with fracture occurrence were assessed using multivariable logistic regression, including age, sex, body mass index z-score (BMI-z), an interaction term between 25OHD and BMI-z, and an additional exploratory model evaluating a 25OHD × season interaction.

The discriminatory ability of 25OHD was evaluated using receiver operating characteristic analysis.

What Was Measured

Other biochemical markers were largely within normal ranges, although ALP levels were modestly higher in fracture patients.

The subject headings attached to it are Adiposity, Alkaline Phosphatase, Biomarkers, Body Mass Index, Case-Control Studies, Fractures, Bone and Logistic Models.

Author keywords: Bone mineralization, Calcium metabolism, Low-energy trauma, Parathyroid hormone, Pediatric bone health and Pediatric fracture.

What This Means in Plain Language

This is an observational study of Parathyroid Hormone (PTH 1-84) in 100 children.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2026 (European journal of pediatrics), a journal based in Germany.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.