Evaluation of surrogate biomarkers of memory and cognition in aging adults with vitamin B12 deficiency: A cross-sectional study.

What Was Tested

Researchers studied Cyanocobalamin (Vitamin B12) in this observational study publication.

This study aims to evaluate cognitive and memory-related biomarkers in otherwise healthy aging adults with vitamin B12 deficiency and to explore whether it is an under recognized contributor to dementia.

Why It Was Studied

Vitamin B12 (Vit B12) is a cofactor in one-carbon metabolism, methylation reactions, myelin synthesis, and neuronal function.

Its deficiency can lead to neurodegeneration and cognitive decline.

Who Took Part

The abstract describes 3 participants taking part.

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

Serum levels of Aβ42, acetylcholinesterase (AChE), brain derived neurotrophic factor (BDNF), GSH, and calcium were estimated in ninety healthy individuals, aged between 45 to 65 years.

They were divided into 3 groups of 30 participants each, as vit B12 sufficient (>300 pg/ml), insufficient (201-300 pg/ml) and deficient (≤200pg/ml) groups.

How the Study Was Run

Serum BDNF and Aβ42 were estimated by sandwich ELISA.

Calcium, GSH and AChE were measured spectrophotometrically.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Vitamin B 12 Deficiency, Amyloid beta-Peptides, Brain-Derived Neurotrophic Factor, Cross-Sectional Studies, Cognition and Aging.

The authors tagged it with the keywords Aβ42, BDNF, Cognitive markers, Dementia and Vitamin B12 deficiency.

What This Means in Plain Language

This is an observational study of Cyanocobalamin (Vitamin B12) in 3 participants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (La Clinica terapeutica), a journal based in Italy.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.