The effects of oral magnesium supplements on vascular and endothelial function: an updated systematic review and meta-analysis of randomized controlled trials.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

This systematic review and meta-analysis aimed to update and evaluate the effect of magnesium supplementation on vascular function and cardiometabolic outcomes in adults.

Who the Included Studies Covered

PubMed indexes the participants as young adults, adults, middle-aged adults and older adults, both men and women.

A systematic search based on PRISMA 2020 guidelines was conducted on PubMed, Web of Science, Scopus, CENTRAL, and ClinicalTrials.gov up to 23 April 2026 to include randomized placebo-controlled trials assessing the effects of magnesium supplementation on flow-mediated dilation (FMD), pulse wave velocity (PWV), and carotid intima-media thickness (CIMT), and as secondary outcomes for serum magnesium levels and systolic and diastolic blood pressure.

What Was Measured

This systematic review and meta-analysis aimed to update and evaluate the effect of magnesium supplementation on vascular function and cardiometabolic outcomes in adults.

The subject headings attached to it are Dietary Supplements, Endothelium, Vascular, Vasodilation, Randomized Controlled Trials as Topic, Magnesium, Vascular Stiffness and Blood Pressure.

Author keywords: Meta-analysis, Systematic review and Vascular function.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (BMC cardiovascular disorders), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.