Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: thigh versus abdomen.

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The absorption of insulin following subcutaneous (s.c.) injection is faster in the abdomen than the thigh.

Ultrasonography of the thigh and abdomen was performed in order to evaluate the thickness of the s.c. tissue.

Who Took Part

PubMed indexes the participants as teenagers and adults, both men and women.

In a cross-over study human GH (Norditropin) was injected s.c. in the thigh or abdomen in random order.

Nine GH deficient patients (five males, four females).

How the Study Was Run

The design is described as randomized and crossover.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the participants took both Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison in turn, acting as their own control.

What Was Measured

Topics PubMed links to this paper include Abdomen, Blood Glucose, Carrier Proteins, Growth Hormone, Growth Inhibitors, Insulin-Like Growth Factor Binding Proteins and Insulin-Like Growth Factor I.

What This Means in Plain Language

The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Results are reported in around 10 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1994 (Clinical endocrinology), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.