Substance P potentiates the algogenic effects of intraarterial infusion of adenosine

What Was Tested

Researchers studied Substance P in this randomized controlled trial publication.

This study investigated whether substance P potentiates the muscular and cardiac pain caused by the intraarterial infusion of adenosine, an autocoid known to induce muscular and cardiac ischemic-like pain in humans.

To test this hypothesis its effects on adenosine-induced muscular and cardiac pain were investigated in humans.

Why It Was Studied

Substance P is involved in the generation of neurogenic inflammation and causes cutaneous hyperalgesia.

Because substance P is present in perivascular nerves it might also cause muscular and cardiac hyperalgesia.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized and crossover study.

Because people in this Substance P study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Each person switched between Substance P and the comparison at some point, usually with a gap in between.

Pain severity, assessed by a visual analog scale, is presented as median.

The remaining data are presented as mean value +/- 1 SD.

What Was Measured

Topics PubMed links to this paper include Adenosine, Chest Pain, Coronary Vessels, Drug Synergism, Iliac Artery, Infusions, Intra-Arterial and Pain.

What This Means in Plain Language

The paper is a randomized and crossover study of Substance P.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1994 (Journal of the American College of Cardiology), a journal based in United States.

More context: the Substance P compound page, all human trials.