Randomized prospective study comparing radical prostatectomy alone versus radical prostatectomy preceded by androgen blockade in clinical stage B2 (T2bNxM0) prostate cancer. The Lupron Depot Neoadjuvant Prostate Cancer Study Group

What Was Tested

The paper reports a study of Leuprolide, published as a randomized controlled trial.

A multicenter prospective randomized trial compared radical prostatectomy alone to radical prostatectomy after 3 months of leuprolide acetate depot and flutamide in patients with stage cT2bNxM0 prostate cancer and a serum prostate specific antigen level less than 50 ng./ml.

Who Took Part

According to the abstract, 149 patients were involved.

The age groups tagged for this paper are middle-aged adults and older adults, men only.

The researchers randomized 149 patients to undergo androgen deprivation and 138 to undergo lymphadenectomy with (137) or without (1) prostatectomy.

Of the 154 patients randomized to the surgery alone group 144 underwent pelvic node dissection with (138) or without (6) prostatectomy.

How the Study Was Run

The researchers set it up as a randomized and multicenter study.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

More than one site took part, so the patients came from several places.

What Was Measured

Topics PubMed links to this paper include Combined Modality Therapy, Flutamide, Leuprolide, Neoplasm Metastasis, Neoplasm Staging, Preoperative Care and Prostate-Specific Antigen.

What This Means in Plain Language

The paper is a randomized and multicenter study of Leuprolide in 149 patients.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1995 (The Journal of urology), a journal based in United States.

More context: the Leuprolide compound page, all human trials.