Energy and macronutrient intake in growth hormone-deficient adults: the effect of growth hormone replacement.

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

To assess the energy intake and the macronutrient composition of the diet in 25 growth hormone-deficient (GHD) patients before, and after 3 and 6 months replacement with recombinant human growth hormone (rhGH).

Who Took Part

The abstract describes 25 patients taking part.

The age groups tagged for this paper are infants, young children, children, teenagers, adults, middle-aged adults, older adults and people over 80, both men and women.

The energy and macronutrient intake of the GHD patients at baseline were compared with the data obtained in the Dutch Nutritional Survey.

Department of Endocrinology, University Hospital Utrecht, Utrecht, The Netherlands.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.

The study had a randomised double-blind placebo-controlled design.

Energy intake was assessed by the 4-day food record and 24-h urine total nitrogen excretion was used as a check on the validity.

Fat-free mass (FFM) and body fat (BF) were assessed by bioelectrical impedance analysis (BIA).

25 GHD patients, aged 21-60 years.

What Was Measured

The subject headings attached to it are Body Composition, Diet, Energy Intake, Growth Hormone, Insulin-Like Growth Factor I, Nitrogen and Nutritional Physiological Phenomena.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 25 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1995 (European journal of clinical nutrition), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.