In vitro fertilisation and gamete intrafallopian transfer: an integrative analysis of research, 1987-1992.

What It Covers

This review looks at Clomiphene.

To provide a statistically integrated analysis and review of all published outcome studies of in vitro fertilisation (IVF) and gamete intrafallopian transfer (GIFT) occurring in English language journals between 1987 and 1992; to provide information regarding outcome of assisted reproduction not otherwise available from national registers; and to assess correspondence of these outcomes with outcome data presented in the national registers of the Fertility Societies of Australia and the United States.

Who the Included Studies Covered

PubMed tags the participants as women only.

A secondary analysis of three factors, including 1. treatment (IVF vs GIFT), 2. stimulation protocol [combinations using clomiphene citrate (CC), combinations using gonadotrophin agonists (GnRHa), and combinations using neither clomiphene citrate nor gonadotrophin agonists, (designated by the symbols and acronyms approximately CC approximately GnRHa throughout this article)], and 3. cause of infertility, assessed their impact upon three clinical pregnancy rates: 1. cycles commenced, 2. cycles reaching retrieval and 3. cycles reaching oocyte/embryo transfer, via a series of one-way analyses of variance with either planned contrasts or post hoc comparisons.

Data were obtained from 31 journals and 216 papers, containing 509 samples and 39,754 per cycles commenced.

How the Review Was Done

Computer literature review and manual search of major infertility journals to identify all papers reporting clinical pregnancy rates for IVF and GIFT.

The unit of observation was the published study.

Data from the national registers of the Fertility Societies of Australia and the United States were used for comparison of literature-based outcomes, where appropriate.

What Was Measured

PubMed files the paper under topics including Chorionic Gonadotropin, Clomiphene, Fertilization in Vitro, Gamete Intrafallopian Transfer and Ovulation Induction.

What This Means in Plain Language

This is a review of Clomiphene.

Results are reported in around 14 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1995 (British journal of obstetrics and gynaecology), a journal based in England.

More context: all human trials.