Comparison of human menopausal gonadotropin and follicle-stimulating hormone with gonadotropin-releasing hormone agonist desensitization for controlled ovarian hyperstimulation in in vitro fertilization

What Was Tested

The paper reports a study of HMG (Human Menopausal Gonadotropin) and Leuprolide, published as a randomized controlled trial.

A pregnancy in patients treated with gonadotropin-releasing hormone agonists (GnRHa) using follicle-stimulating hormone (FSH) alone was first reported by Shaw et al. in 1991.

In other words, the residual endogenous levels of luteinizing hormone (LH) in GnRHa treated cycles may be generally sufficient to support FSH-induced follicular development to exempt from the co-administration of exogenous LH.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

After the pituitary gland was down-regulated, all patients were given either hMG (n = 25) or FSH (n = 17) for controlled ovarian hyperstimulation (COH).

How the Study Was Run

In design terms this was a randomized study.

Because people in this HMG (Human Menopausal Gonadotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A total of 42 consecutive candidates for in vitro fertilization (IVF) participated in a prospective randomized study.

Ovarian inactivity was monitored by plasma estradiol and LH concentration.

What Was Measured

In other words, the residual endogenous levels of luteinizing hormone (LH) in GnRHa treated cycles may be generally sufficient to support FSH-induced follicular development to exempt from the co-administration of exogenous LH.

Topics PubMed links to this paper include Fertilization in Vitro, Follicle Stimulating Hormone, Leuprolide, Menotropins, Ovary and Triptorelin Pamoate.

What This Means in Plain Language

The paper is a randomized study of HMG (Human Menopausal Gonadotropin) and Leuprolide.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1995 (Zhonghua yi xue za zhi = Chinese medical journal; Free China ed), a journal based in China (Republic : 1949- ).

More context: the HMG (Human Menopausal Gonadotropin) compound page and the Leuprolide compound page, all human trials.