Substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients

Plain-language guide to PMID 7687608 (1993): randomized controlled trial study of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide).

Key Facts

PMID: 7687608
Journal: The Journal of allergy and clinical immunology
Year: 1993
Study type: Randomized Controlled Trial
Authors: Mosimann BL et al. (6 authors)
DOI: 10.1016/0091-6749(93)90043-f

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide), published as a randomized controlled trial.

Substance P (SP) and calcitonin gene-related peptide (CGRP) are released by sensory nerves, whereas vasoactive intestinal peptide (VIP) is released mainly by parasympathetic nerves.

Both sets of nerves are thought to be stimulated by allergic inflammation.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

How the Study Was Run

In design terms this was a randomized study.

The participants were allocated by chance, so the VIP (Vasoactive Intestinal Peptide) group and the comparison group should start out alike.

Nasal lavages were collected into a cocktail of protease inhibitors in order to restrict neuropeptide degradation.

Radioimmunoassay for SP, CGRP, and VIP were performed on each sample.

What Was Measured

Substance P (SP) and calcitonin gene-related peptide (CGRP) are released by sensory nerves, whereas vasoactive intestinal peptide (VIP) is released mainly by parasympathetic nerves.

PubMed files the paper under topics including Allergens, Calcitonin Gene-Related Peptide, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Histamine, Nasal Mucosa and Nasal Provocation Tests.

What This Means in Plain Language

The paper is a randomized study of VIP (Vasoactive Intestinal Peptide) and CGRP (Calcitonin Gene-Related Peptide).

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1993 (The Journal of allergy and clinical immunology), a journal based in United States.

More context: the VIP (Vasoactive Intestinal Peptide) compound page and the CGRP (Calcitonin Gene-Related Peptide) compound page, all human trials.

Our Notes on the Compounds

VIP (Vasoactive Intestinal Peptide): A 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune activity; aviptadil is a synthetic form.

CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.

Substance P: An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.