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Growth hormone responses to dexamethasone in healthy females throughout the menstrual cycle.
Plain-language guide to PMID 7704961 (1995): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 7704961
- Journal
- Clinical endocrinology
- Year
- 1995
- Study type
- Randomized Controlled Trial
- Authors
- Thakore JH et al. (2 authors)
- DOI
- 10.1111/j.1365-2265.1995.tb01859.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.
In health, acute administration of dexamethasone (DEX) leads to growth hormone release.
As sex steroids have a profound influence on the somatotrophic axis, the researchers decided to investigate the effects of DEX on GH release throughout the menstrual cycle.
Who Took Part
By PubMed's age tags, the people studied were adults, women only.
A within subjects, randomized double-blind counter-balanced design was employed.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.
Plasma samples for GH estimation were taken at 60, 180, 240 and 300 minutes.
Each woman was tested 6 times, 3 times with placebo and 3 times with DEX.
Plasma GH, oestradiol and progesterone were measured by radioimmunoassay.
What Was Measured
Topics PubMed links to this paper include Dexamethasone, Estradiol, Growth Hormone, Menstrual Cycle, Progesterone and Stimulation, Chemical.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 1995 (Clinical endocrinology), a journal based in England.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.