Diurnal variation of growth hormone responses to acutely administered dexamethasone in healthy male volunteers.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

The purpose of this study was to examine the effects of the diurnal variation of plasma cortisol on dexamethasone (DEX)-induced GH responses in healthy volunteers.

Why It Was Studied

Acute administration of exogenous corticosteroids stimulates growth hormone (GH) release.

Physiological fluctuations of plasma cortisol appear to have an effect on the circadian release of GH.

Who Took Part

PubMed indexes the participants as adults, men only.

How the Study Was Run

The design is described as randomized and crossover.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.

What Was Measured

Subjects were tested twice, with an interval of two weeks between tests, at 9.00 h and 14.00 h.

PubMed files the paper under topics including Circadian Rhythm, Dexamethasone, Growth Hormone and Hydrocortisone.

What This Means in Plain Language

The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 1995 (Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme), a journal based in Germany.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.