Long-term GnRH-agonist treatment does not postpone central development of the GnRH pule generator in girls with idiopathic precocious puberty.

What Was Tested

The paper reports a study of Gonadotropin-Releasing Hormone, published as a randomized controlled trial.

The protocol included 24-h sampling of blood at 10-min intervals just before GnRH-agonist treatment (group 1, n = 7), and at 4 and 10 months after discontinuation of treatment (group 2, n = 8).

LH was estimated at 10-min intervals, and FSH and estradiol were estimated at 1-h intervals for 6-h periods during the day (wake) and during the night (sleep).

Who Took Part

PubMed indexes the participants as young children and children, women only.

How the Study Was Run

The design is described as randomized.

Because people in this Gonadotropin-Releasing Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In group 2, height was measured in the follow-up at 4 and at 10 months.

What Was Measured

At both sampling periods, no wake sleep differences in LH pulse frequency, mean LH levels, or LH pulse amplitude were observed.

Topics PubMed links to this paper include Body Height, Child Development, Gonadotropin-Releasing Hormone, Luteinizing Hormone, Menarche, Ovary and Ovulation.

What This Means in Plain Language

The paper is a randomized study of Gonadotropin-Releasing Hormone.

The publication is from 1995 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: all human trials.