← Human Trials & Peer-Reviewed Studies
The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults.
Plain-language guide to PMID 7758229 (1995): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Key Facts
- PMID
- 7758229
- Journal
- Clinical endocrinology
- Year
- 1995
- Study type
- Randomized Controlled Trial
- Authors
- Beshyah SA et al. (5 authors)
- DOI
- 10.1111/j.1365-2265.1995.tb01872.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The researchers report on the effects of 12-18 months of GH replacement treatment with biosynthetic human GH on bone metabolism and bone mass in hypopituitary adults.
Who Took Part
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized and double-blind.
Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
Plasma calcium, phosphate and intact PTH concentrations, 24-hour urinary calcium excretion, 3 markers of bone formation (total alkaline phosphatase, osteocalcin and procollagen 1 carboxy terminal peptide (P1CP)) and serum concentration of carboxyterminal cross-linked telopeptide of type 1 collagen (ICTP), as a marker of bone resorption, were measured at 6-month intervals.
Lumbar spine and total body bone mineral mass was measured by dual-energy X-ray absorptiometry.
What Was Measured
PubMed files the paper under topics including Absorptiometry, Photon, Alkaline Phosphatase, Bone Density, Bone and Bones, Collagen, Collagen Type I and Growth Hormone.
What This Means in Plain Language
The paper is a randomized and double-blind study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1995 (Clinical endocrinology), a journal based in England.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.