Abu Dhabi third stage trial: oxytocin versus Syntometrine in the active management of the third stage of labour

What Was Tested

This randomized controlled trial paper looks at Oxytocin.

To compare the effect of oxytocin and Syntometrine when used as part of active management of third stage of labour on postpartum haemorrhage, hypertension, nausea/vomiting and retained placenta.

Who Took Part

According to the abstract, 1991, women were involved.

By PubMed's age tags, the people studied were adults, women only.

Between 1 January 1991 and 30 June 1991, 2040 women were randomly allocated either to the oxytocin (n = 1017) or the Syntometrine (n = 1023) group.

Twelve patients had to be excluded from the trial (oxytocin, 5; Syntometrine, 7) after randomisation because they no longer fulfilled the inclusion criteria.

How the Study Was Run

The design is described as randomized and double-blind.

The women were allocated by chance, so the Oxytocin group and the comparison group should start out alike.

Blinding on both sides kept the women and researchers unaware of who received Oxytocin.

A randomised double blind trial was conducted in the Obstetric Unit of Corniche Hospital, Abu Dhabi in the United Arab Emirates.

What Was Measured

Topics PubMed links to this paper include Ergonovine, Labor Stage, Third, Oxytocics, Oxytocin, Postpartum Hemorrhage and United Arab Emirates.

What This Means in Plain Language

The paper is a randomized and double-blind study of Oxytocin in 1991, women.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1995 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.

More context: the Oxytocin compound page, all human trials.