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Automatic needle insertion diminishes pain during growth hormone injection.
Plain-language guide to PMID 7780258 (1995): crossover randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 18 children.
Key Facts
- PMID
- 7780258
- Journal
- Acta paediatrica (Oslo, Norway : 1992)
- Year
- 1995
- Study type
- Randomized Controlled Trial
- Authors
- Main KM et al. (5 authors)
- DOI
- 10.1111/j.1651-2227.1995.tb13638.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.
Non-compliance in children receiving growth hormone (GH) treatment is often caused by pain on injection and difficulties in administration of GH.
The researchers quantitatively measured pain intensity on injection with two prototype pens for GH administration, providing either manual or automatic sc needle insertion, using a combined visual analogue/facial scale and a five-item scale in 18 children.
Who Took Part
According to the abstract, 18 children were involved.
The age groups tagged for this paper are children and teenagers, both men and women.
How the Study Was Run
The researchers set it up as a randomized and crossover study.
Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.
Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.
What Was Measured
The researchers quantitatively measured pain intensity on injection with two prototype pens for GH administration, providing either manual or automatic sc needle insertion, using a combined visual analogue/facial scale and a five-item scale in 18 children.
Topics PubMed links to this paper include Facial Expression, Growth Disorders, Growth Hormone, Injections, Needles, Pain and Pain Measurement.
What This Means in Plain Language
The paper is a randomized and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 18 children.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1995 (Acta paediatrica (Oslo, Norway : 1992)), a journal based in Norway.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.